OMIP‐047: High‐Dimensional phenotypic characterization of B cells
نویسندگان
چکیده
منابع مشابه
Frequency and characterization of phenotypic Ig heavy chain allelically included IgM-expressing B cells in mice.
Ig H chain (IgH) allelic exclusion remains a puzzling topic. Here, we address the following question: Do phenotypic IgH allelically included cells exist in normal mice and, if so, at what frequency? Sorted cells from heterozygous mice were evaluated for the expression of both IgM allotypes by double intracytoplasmic stainings. Dual expressors were found at a frequency of 1 in 104 splenic B cell...
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INTRODUCTION In chronic inflammatory disorders, B cells can contribute to tissue damage by autoantibody production and antigen presentation to T cells. Here, we have characterized synovial fluid and tissue B-cell subsets in patients with oligoarticular juvenile idiopathic arthritis (JIA), an issue not addressed before in detail. METHODS B cells from synovial fluid (SF) and peripheral blood (P...
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DNA-reactive B cells play a central role in systemic lupus erythematosus (SLE); DNA antibodies precede clinical disease and in established disease correlate with renal inflammation and contribute to dendritic cell activation and high levels of type 1 interferon. A number of central and peripheral B cell tolerance mechanisms designed to control the survival, differentiation and activation of aut...
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Yann M. Kerdiles,1,8,* Francisca F. Almeida,2,3,8 Thornton Thompson,4,8 Michael Chopin,2,3,8 Margaux Vienne,1 Pierre Bruhns,5,6 Nicholas D. Huntington,2,3 David H. Raulet,4,9 Stephen L. Nutt,2,3,9 Gabrielle T. Belz,2,3,9 and Eric Vivier1,7,9 1Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille, France 2Walter and Eliza Hall Institute of Medical Research, ...
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Nutrient-evoked gastrointestinal reflexes are likely initiated by specialized epithelial cells located in the small intestine that detect luminal stimuli and release mediators that activate vagal endings. The G-protein alpha-gustducin, a key signal molecule in lingual taste detection, has been identified in mouse small intestine, where it may also subserve nutrient detection; however, the pheno...
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ژورنال
عنوان ژورنال: Cytometry Part A
سال: 2018
ISSN: 1552-4922,1552-4930
DOI: 10.1002/cyto.a.23488